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Publications - F.B. Da Costa

Original Articles in Journals
114.Padilla-Gonzalez, G.F.; Diazgranados, M.; Da Costa, F.B. Effect of the Andean geography and climate on the specialized metabolism of its vegetation: the subtribe Espeletiinae (Asteraceae) as a case example. Metabolites, v. 11, p. 220, 2021.
113.Freitas, J.A.; Ccana-Ccapatinta, G.V.; Da Costa, F.B. LC-MS metabolic profiling comparison of domesticated crops and wild edible species from the family Asteraceae growing in a region of São Paulo state, Brazil. Phytochemistry Letters, v. 42, p. 45-51, 2021.
112.Freitas, J.A.; Ccana-Ccapatinta, G.V.; Da Costa, F.B. Pyrrolizidine alkaloids and other constituents from Emilia fosbergii Nicolson. Biochemical Systematics and Ecology, v. 92, p. 104110, 2020.
111.Padilla-Gonzalez, G.F.; Amrehn, E.; Frey, M.; Gomez-Zeledon, J.; Kaa, A; Da Costa, F. B.; Spring, O. Metabolomic and gene expression studies reveal the diversity, distribution and spatial regulation of the specialized metabolism of yacón (Smallanthus sonchifolius, Asteraceae). International Journal of Molecular Sciences, v. 21, p. 4555, 2020.
110.Ccana-Ccapatinta, G.V.; Freitas, J.A.; Monge, M.; Ferreira, P.L.; Semir, J.; Groppo, M.; Da Costa, F.B. Metabolomics and chemophenetics support the new taxonomy circumscription of two South America genera (Barnadesioideae, Asteraceae). Phytochemistry Letters, v. 40, p. 89-95, 2020.
109.Gonzalez, E.P.; Casoti, R.; Murillo, M.A.; Da Costa, F.B.; Suarez, L.C. Metabolomic profiling of Zanthoxylum species: identification of anti-cholinesterase alkaloids candidates. Phytochemistry, v. 168, p. 112128, 2019.
108.Padilla-Gonzalez, G.F.; Frey, M.; Gómez-Zeledón, J. Da Costa, F.B.; Spring, O. Metabolomic and gene expression approaches reveal the developmental and environmental regulation of the secondary metabolism of yacón (Smallanthus sonchifolius, Asteraceae)Scientific Reports, v. 9, p. 13178, 2019.
107.Ccana-Ccapatinta, G.V.; Ferreira, P.L.; Groppo, M.; Da Costa, F.B. Caffeic acid ester derivatives and flavonoids of genus Arnaldoa (Asteraceae, Barnadesioideae). Biochemical Systematics and Ecology, v. 86, p. 103911, 2019.
106.Chibli, L.A.; Rosa, A.L.; Nonato, M.C.; Da Costa, F.B. Untargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase. Metabolomics, v. 15, p. 59, 2019.
105.Sousa, I.P.; Chagas-Paula, D.A.; Tiossi , R.F.J.; Silva, E.O.; Miranda, M.A.; Oliveira, R.B.; Spadaro, A.C.C.; Bastos, J.K.; Furtado, N.A.J.C.; Da Costa, F.B. Essential oils from Tithonia diversifolia display potent anti-oedematogenic effects and inhibit acid production by cariogenic bacteria. Journal of Essential Oil Research, v. 31, p. 43-52, 2019.
104.Santos, F.A.; Sousa, I.P.; Furtado, N.A.J.C.; Da Costa, F.B. Combined OPLS-DA and decision tree as a strategy to identify antimicrobial biomarkers of essential oils analyzed by gas chromatography-mass spectrometry. Brazilian Journal of Pharmacognosy, v.28, p. 647-653, 2018.
103.Fattori, V.; Zarpelon, A.C.; Staurengo-Ferrari, L.; Borghi, S.M.; Zanielli, T.H.; Da Costa, F.B.; Alves-Filho, J.C.; Cunha, T.M.; Cunha, F.Q.; Casagrande, R.; Arakawa, N.S.; Verri, W.A. Budlein A, a sesquiterpene lactone from Viguiera robusta, alleviates pain and inflammation in a model of acute gout arthritis in mice. Frontiers in Pharmacology, v. 9, p. 1076, 2018.
102.Chibli, L.A.; Schmidt, T.J.; Nonato, M.C.; Calil, F.A.; Da Costa, F.B. Natural products as inhibitors of Leishmania major Dihydroorotate Dehydrogenase. European Journal of Medicinal Chemistry, v. 157, p. 852-866, 2018.
101.Souza, M.C.; Rosa, A.L.; Poschenrieder, C.; Tolrà, R.; Da Costa, F.B. Fingerprinting metabolomics in tropical mistletoes: A case study with facultative aluminum-accumulating species. Phytochemistry Letters, v. 25,p. 90–94, 2018.
100.Souza, M.C.; Scalon, M.C.; Poschenrieder, C.; Tolrà, R.; Venâncio, T.; Teixeira, S.P.Da Costa, F.B. Aluminium detoxification in facultative (Passovia ovata (Pohl ex DC.) Kuijt and Struthanthus polyanthus Mart. - Loranthaceae) and dependent (Psittacanthus robustus (Mart.) Marloth - Loranthaceae) Al-accumulating mistletoe species from the Brazilian savanna. Phytochemistry, v. 153, p. 58-63, 2018. 
99.Sampaio, B.L.; Da Costa, F.B. Influence of abiotic environmental factors on the main constituents of the volatile oils of Tithonia diversifolia. Brazilian Journal of Pharmacognosy, v. 28, p. 135-144, 2018.
98.Gallon, M.E.; Monge, M.; Casoti, R.; Da Costa, F.B.; Semir, J.; Gobbo-Neto, L. Metabolomics analysis applied to chemosystematics and evolution of megadiverse Brazilian Vernonieae (Asteraceae). Phytochemistry, v. 150, p. 93-105, 2018.
97.Souza, M.C.; Scalon, M.C.; Poschenrieder, C.; Tolrà, R.; Venâncio, T.; Teixeira, S.P.; Da Costa, F.B. Mechanisms of storage and detoxification of Al in two tropical mistletoes. Environmental and Experimental Botany, v. 150, p. 37-45, 2018.
96.Scotti, M.T.; Herrera-Acevedo, C.; Oliveira, T.B.; Costa, R.P.O.; Santos, S.Y.K.O.; Rodrigues, R.P.; Scotti, L.; Da Costa, F.B. SistematX, an online web-based cheminformatics tool for data management of secondary metabolitesMolecules, v. 23, p. 103, 2018.
95.Ccana-Ccapatinta, G.V; Monge, M.; Ferreira, P.L.; Da Costa, F.B. Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae). Phytochemistry Reviews, v. 17, p. 471-489, 2018.
94.Gonzalez, G.F.P.; Diazgranados, M.; Oliveira, T.B.; Chagas-Paula, D.A.; Da Costa, F.B. Chemistry of the subtribe Espeletiinae (Asteraceae) and its correlation with phylogenetic data: an in silico chemosystematic approach. Botanical Journal of the Linnean Society, v. 186, p. 18-46, 2017.
93.Ccana-Ccapatinta, G.V.; Sampaio, B.L.; Santos Jr., F.M.; Batista, J.M.; Da Costa, F.B. Absolute configuration assignment of caffeic acid ester derivatives from Tithonia diversifolia by vibrational circular dichroism: the pitfalls of deuteration. Tetrahedron-Asymmetry, v. 28, p. 1823-1828, 2017.
92.Padilla-Gonzalez, G.F.; Diazgranados, M.; Da Costa, F.B. Biogeography shaped the metabolome of the genus Espeletia: a phytochemical perspective on an Andean adaptive radiationScientific Reports, v. 7, p. 8835, 2017.
91.Zarpelon, A.C.; Fattori, V.; Souto, F.O.; Pinto, L.G.; Pinho-Ribeiro, F.A.; Ruiz-Miyazawa, K.W.; Turato, W.M.; Cunha, T.M.; Da Costa, F.B.;  Cunha, F.Q.; Casagrande, R.; Arakawa, N.S.; Verri, W.A. The sesquiterpene lactone, budlein A, inhibits antigen-induced arthritis in mice: role of NF-kB and cytokines. Inflammation, v. 40, p. 2020–2032, 2017.
90.Souza, M.C.; Habermann, G.; Amaral, C.L.; Rosa, A.L.; Pinheiro, M.H.O.; Da Costa, F.B. Vochysia tucanorum Mart.: an aluminum-accumulating species evidencing calcifuge behavior. Plant and Soil, v. 419, p. 377–389, 2017
89.Wulsten, I.F.; Costa-Silva, T.A.; Mesquita, J.T.; Lima, M.L.; Galuppo, M.K.; Taniwaki, N.N.; Borborema, S.E.T.; Da Costa, F.B.; Schmidt, T.J.; Tempone, A.G. Investigation of the anti-Leishmania (Leishmania) infantum activity of some natural sesquiterpene lactones. Molecules, v. 22, p. 685, 2017.
88.Padilla-Gonzalez, G.F.; Diazgranados, M.; Ccana-Ccapatinta, G.V.; Casoti, R.; Da Costa, F.B. Caffeic acid derivatives and further compounds from Espeletia barclayana Cuatrec. (Asteraceae, Espeletiinae)Biochemical Systematics and Ecology , v. 70, p. 291-293, 2017.
87.Knob, C.D.; Silva, M.; Gasparoto, T.H.; Oliveira, C.E.; Amôr, N.G; Arakawa, N.S; Da Costa, F.B.; Campanelli, A.P. Effects of budlein A on human neutrophils and lymphocytes. Journal of Applied Oral Science, v. 24, p. 271-277, 2016.
86.Lusa, M.G.; Martucci, M.E.P.; Loeuille, B.F.P.; Gobbo-Neto, L.; Appezzato-da-Glória, B.; Da Costa, F.B. Characterization and evolution of secondary metabolites in Brazilian Vernonieae (Asteraceae) assessed by LC-MS fingerprinting. Botanical Journal of the Linnean Society, v. 182, p. 594-611, 2016. 
85.Lusa, M.G.; Da Costa, F.B.; Appezzato-da-Glória, B. Histolocalization of chemotaxonomic markers in Brazilian Vernonieae (Asteraceae). Botanical Journal of the Linnean Society, v. 182, p. 581-593, 2016. 
84.Lopes, A.A.; Pina, E.S.; Nader, T.T.; Da Costa, FB.; Pereira, A.M.S.; Pupo, M.T. Biosynthesis of (−)-ent-kaurenoic acid in Smallanthus sonchifolius and its effect against microbial biofilms. Phytochemistry Letters, v. 18, p. 162-167, 2016. 
83.Nogueira, M.S.; Da Costa, F.B.; Brun, R.; Kaiser, M.; Schmidt, T.J. ent-Pimarane and ent-kaurane diterpenes from Aldama discolor (Asteraceae) and their antiprotozoal activity. Molecules, v. 21, p. 1237, 2016. 
82.Padilla-Gonzalez, G.F.; Mejia, J.A.A.; Da Costa, F.B. Chemical characterization of two morphologically related Espeletia (Asteraceae) species and chemometric analysis based on essential oil components. Brazilian Journal of Pharmacognosy, v. 26, 694-700, 2016. 
81.Sampaio, B.L.; Edrada-Ebel, R.; Da Costa, F.B. Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants. Scientific Reports, v. 6, 29265, 2016. 
80.Padilla-Gonzalez, G.F.; Santos, F.A.; Da Costa, F.B. Sesquiterpene lactones: more than protective plant compounds with high toxicity. Critical Reviews in Plant Sciences, v. 35, p. 01-20, 2016. 
79.Lemos, L.M.S.; Oliveira, R.B.; Sampaio, B.L.; Ccana-Ccapatinta, G.V.; Da Costa, F.B.; Martins, D.T.O. Brasiliensic and isobrasiliensic acids: isolation from Calophyllum brasiliense Cambèss. and anti-Helicobacter pylori activity. Natural Products Research, v. 30, p. 01-16, 2016.
78.Chagas-Paula, D.A.; Oliveira, T.B.; Faleiro, D.P.V.; Oliveira, R.B.; Da Costa, F.B. Outstanding anti-inflammatory potential of selected Asteraceae species through the potent dual inhibition of cyclooxygenase-1 and 5-lipoxygenase. Planta Medica, v. 81, p. 1296-1307, 2015. 
77.Souza, M.C.; Amaral, C.L.; Habermann, G.; Alves, P.L.C.A.; Da Costa, F.B. Non-destructive model to estimate the leaf area of multiple Vochysiaceae species. Brazilian Journal of Botany, v. 38, p. 1-7, 2015. 
76.Chagas-Paula, D.A.; Zhang, T.; Da Costa, F.B.Edrada-Ebel, R. A metabolomic approach to target compounds from the Asteraceae family for dual COX and LOX inhibition. Metabolites, v. 5, p. 404-430, 2015. 
75.Abe, A.E.; Oliveira, C.E.; Dalboni, T.M.; Chagas-Paula, D.A.; Rocha, B.A.; Oliveira, R.B.; Gasparoto, T.H.; Da Costa, F.B.; Campanelli, A.P. Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils. Brazilian Journal of Pharmacognosy, v. 25, p. 111-116, 2015. 
74.Chagas-Paula, D.A.; Oliveira, T.B.; Zhang, T.; Edrada-Ebel, R.; Da Costa, F.B. Prediction of anti-inflammatory plants and discovery of their biomarkers by machine learning algorithms and metabolomic studies. Planta Medica, v. 81, p. 450-458, 2015. 
73.Oliveira, T.B.; Gobbo-Neto, L.; Schmidt, T.J.; Da Costa, F.B. Study of chromatographic retention of natural terpenoids by chemoinformatic tools. Journal of Chemical Information and Modeling, v. 55, p. 26-38, 2015.
72.Sass, D.C.; Morais, G.O.; Miranda, R.C.; Magalhães, L.G.; Cunha, W.R.; Santos, R.A.; Arakawa, N.S.; Da Costa, F.B.; Constantino, M.G.; Heleno, V.C. Structurally modified natural sesquiterpene lactones constitute effective and less toxic schistosomicidal compounds. Organic & Biomolecular Chemistry, v. 12, p. 7957-7964, 2014.
71.Toledo, J.S.; Ambrosio, S.R.; Borges, C.H.G.; Manfrim, V.; Cerri, D.G.; Cruz, A.K.; Da Costa, F.B. In vitro leishmanicidal activities of sesquiterpene lactones from Tithonia diversifolia against Leishmania braziliensis promastigotes and amastigotes. Molecules, v. 19, p. 6070-6079, 2014. 
70.Sartori, L.R; Vessecchi, R.; Humpf, H.-U.; Da Costa, F.B.; Lopes, N.P. A systematic investigation of the fragmentation pattern of two furanoheliangolides C-8 stereoisomers using electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, v. 28, p. 723-730, 2014. 
69.Schmidt, T.J.; Da Costa, F.B.; Lopes, N.P.; Kaiser, M.; Brun, R. In silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrobial Agents and Chemotherapy, v. 58, p. 325-332, 2013. 
68.Arakawa, N.S.; Gobbo-Neto, L.; Ambrosio, S.R.; Antonucci, G.A.; Sampaio, S.V.; Pupo, M.T.; Said, S.; Schmidt, T.J.; Da Costa, F.B. Unusual biotransformation products of the sesquiterpene lactone budlein A by Aspergillus species. Phytochemistry, v. 96, p. 92-100, 2013.
67.Oliveira, J.F.F.; Garreto, D.V.; Silva, M.C.P.; Fortes, T.S.; Oliveira, R.B.; Nascimento, F.R.F.; Da Costa, F.B.; Grisotto, M.A.G.; Nicolete, R. Therapeutic potential of biodegradable microparticles containing Punica granatum L. (pomegranate) in murine model of asthma. Inflammation Research, v. 62, p. 971-980, 2013.
66.Rafael, J.A.; Arakawa, N.S.; Ambrosio, S.R.; Da Costa, F.B.; Said, S. Hyphal morphology and elongation alterations in Aspergillus nidulans provoked by the diterpene kaurenoic acid. Advances in Microbiology, v. 3, p. 438-441, 2013.
65.Igual, M.O.; Martucci, M.E.P.; Da Costa, F.B.; Gobbo-Neto, L. Sesquiterpene lactones, chlorogenic acids and flavonoids from leaves of Vernonia polyanthes Less (Asteraceae). Biochemical Systematics and Ecology, v. 51, p. 94-97, 2013. 
64.Lopes, A.A.; Pina, E.S.; Silva, D.B.; Pereira, A.M.S.; Da Silva, M.F.G.F.; Da Costa, F.B.; Lopes, N.P.; Pupo, M.T. A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging. Chemical Communications, v. 49, p. 9989-9991, 2013.
63.Oliveira, R.B.; Chagas-Paula, D.A.; Secatto, A.; Gasparoto, T.H.; Faccioli, L.H.; Campanelli, A.P.; Da Costa, F.B. Topical anti-inflammatory activity of yacon leaf extracts. Brazilian Journal of Pharmacognosy, v. 23, pp. 497-505, 2013.
62.Passoni, F.D.; Oliveira, R.B.; Chagas-Paula, D.A.; Gobbo-Neto, L.; Da Costa, F.B. Repeated-dose toxicological studies of Tithonia diversifolia (Hemsl.) A. Gray and identification of the toxic compounds. Journal of Ethnopharmacology, v. 147, pp. 389-394, 2013.
61.Schomburg, C.; Schuehly, W.; Da Costa, F.B.; Klempnauer, K.-H.; Schmidt, T.J. Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships. European Journal of Medicinal Chemistry, v. 63, pp. 313-320, 2013.
60.Sass, D.C.; Heleno, V.C.G.; Barbosa, J.S.; Morais, G.O.; Da Costa, F.B.; Constantino, M.G. Biomimetic synthesis of diversifolin. Tetrahedron Letters, v. 54, pp. 625-627, 2013. 
59.Cortes-Rojas, D.F.; Chagas-Paula, D.A.; Da Costa, F.B.; Souza, C.R.F.; Oliveira, W.P. Bioactive compounds in Bidens pilosa L. populations: a key step in the standardization of phytopharmaceutical preparations. Revista Brasileira de Farmacognosia, v. 23, pp. 28-35, 2012. 
58.Appezzato-da-Glória, B.; Da Costa, F.B.; Silva, V.C.; Gobbo-Neto, L.; Rehder, V.L.G.; Hayashi, A.H. Glandular trichomes on aerial and underground organs in Chrysolaena species (Vernonieae – Asteraceae): structure, ultrastructure and chemical composition. Flora, v. 207, pp. 878–887, 2012.
57.Rocha, B.A.; Pupo, M.T.; Antonucci, G.A.; Sampaio, S.V.; Paiva, R.M.A.; Said, S.; Gobbo-Neto, L.; Da Costa, F.B. Microbial transformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus. Journal of Industrial Microbiology & Biotechnology v. 39, pp. 1719-1724, 2012.
56. Chagas-Pula, D.A.; Oliveira, R.B.;Rocha, B. A.; Da Costa, F.B. Ethnobotany, chemistry and biological activities of the genus Tithonia (Asteraceae). Chemistry & Biodiversity, v. 9, pp. 210-235, 2012. 
55. Schmidt, T.J.; Khalid, S.A; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, FB.; Castro, S.L.; Ferreira, V.F.; Lacerda, M.V.G.; Lago, J.H.G.; Leon, L.L.; Lopes, N.P.; Amorin, R.C.N.; Niehues, M.; Ogungbe, I.V.; Pohlit, A.M.; Scotti, M.T.; Setzer, W.N.; Soeiro, M.N.C.; Steidel, M.; Tempone, A.G. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases Part I. Current Medicinal Chemistry, v. 19, pp. 2128-2175, 2012. 
54.Schmidt, T.J.; Khalid, S.A; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, FB.; Castro, S.L.; Ferreira, V.F.; Lacerda, M.V.G.; Lago, J.H.G.; Leon, L.L.; Lopes, N.P.; Amorin, R.C.N.; Niehues, M.; Ogungbe, I.V.; Pohlit, A.M.; Scotti, M.T.; Setzer, W.N.; Soeiro, M.N.C.; Steidel, M.; Tempone, A.G. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases Part II. Current Medicinal Chemistry, v. 19, pp. 2176-2228, 2012.  
53.  Oliveira, R.B.; Chagas-Paula, D.A.; Rocha, B.A.; Franco, J.J.; Gobbo-Neto, L.; Uyemura, S.A.; Santos, W.F.; Da Costa, F.B. Renal toxicity caused by oral use of medicinal plants: the yacon example. Journal of Ethnopharmacology, v. 132, pp. 434-441, 2011. 
52.Carvalho, T.C.; Simão, M.R.; Ambrosio, S.R.; Furtado, N.A. J.C.; Veneziani, R.C.S.; Heleno, V.C.G.; Da Costa, F.B.; Gomes, B.P.F.A.; Souza, M..M.; Borges dos Reis, E.; Martins, C.H.G. Antimicrobial activity of diterpenes from Viguiera arenaria against endodontic bacteria. Molecules, v. 16, pp. 543-551, 2011. 
51.Maas, M.; Hensel, A.; Da Costa, F.B.; Brun, R.; Kaiser, M.; Schmidt, T.J. An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatumPhytochemistry, v. 72, pp. 635-644, 2011. 
50.Chagas-Paula, D.A.; Oliveira, R.B.; Silva, V.C.; Gobbo-Neto, L.; Gasparoto, T.H.; Campanelli, A.P.; Faccioli, L.H.; Da Costa, F.B. Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones. Journal of Ethnopharmacology, v. 136, pp. 355-362, 2011.
49.Garcia, A.F.; Medeiros, H.C.D.; Maioli, M.A.; Lima, M.C.; Rocha, B.A.; Da Costa, F.B.; Curti, C.; Groppo, M.; Mingatto, F.E. Comparative effects of lantadene A and its reduced metabolite on mitochondrial bioenergetics. Toxicon, v. 55, pp. 1331-1337, 2010. 
48.Ambrosio, S.R.; Stefani, R.; Heleno, V.C.G.; Menezes, M.A.; Ferreira, A.G.; Nascimento, P.G.B.D.; Magenta, M.A.G.; Da Costa, F.B. Eudesmanolides and methyl ester derivatives from Dimerostemma arnottiiNatural Product Communications, v. 5, pp. 669-675, 2010. 
47. Porto, T.S.; Rangel, R.; Furtado, N.A.J.C.; Carvalho, T.C.; Martins, C.H.G.; Veneziani, R.C.S.; Da Costa, F.B.; Vinholis, A.H.C.; Cunha, W.R.; Heleno, V.C.G.; Ambrosio, S.R. Pimarane-type diterpenes: antimicrobial activity against oral pathogens. Molecules, v. 14, pp. 191-199, 2009. 
46.Nicolete, R.; Arakawa, N.S.; Rius, C.; Nomizo, A.; Jose, P.J.; Da Costa, F.B.; Sanz, María-Jesús; Faccioli, L.H. Budlein A from Viguiera robusta inhibits leukocyte-endothelial cell interactions, adhesion molecule expression and inflammatory mediators release. Phytomedicine, v. 16, pp. 904-915, 2009.
45. Hipólito, U.V.; Rodrigues, G.J.; Lunardi, C.N.; Bonaventura, D.; Ambrosio, S.R.; Oliveira, A.M.; Bendhack, L.M.; Da Costa, F.B.; Tirapelli, C.R. Mechanisms underlying the vasorelaxant action of the pimarane ent-8(14),15-pimaradien-3beta-ol in the isolated rat aorta. European Journal of Pharmacology, v. 616, pp. 183-191, 2009.
44.Chaves, J.S.; Da Costa, F.B.; Freitas, L.A.P. Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L.). Brazilian Journal of Pharmaceutical Sciences, v. 45, pp. 573-584, 2009. 
43.Porto, T.S.; Furtado, N.A.J.C.; Heleno, V.C.G.; Martins, C.H.G.; Da Costa, F.B.; Severiano, M.E.; Silva, A.N.; Veneziani, R.C.S.; Ambrosio, S.R. Antimicrobial ent-pimarane diterpenes from Viguiera arenaria against Gram-positive bacteria. Fitoterapia, pp. 432-436, 2009.
42.Hristozov, D.; Gasteiger, J.; Da Costa, F.B. Multilabeled classification approach to find a plant source for terpenoids. Journal of Chemical Information and Modeling, v. 48, pp. 56-67, 2008.
41.Ambrosio, S.R.; Furtado, N.A.J.C.; Oliveira, D.C.R.; Da Costa, F.B.; Martins, C.H.G.; Carvalho, T.C.; Veneziani, R.C.S. Antimicrobial activity of kaurane diterpenes against oral pathogens. Zeitschrift für Naturforschung, v. 63c, pp. 326-330, 2008.
40.Tirapelli, C.R.; Ambrosio, S.R.; Da Costa, F.B.; Oliveira, A.M. Diterpenes: a therapeutic promise for cardiovascular diseases. Recent Patent Reviews on Cardiovascular Drug Discovery, v. 3, pp. 1-8, 2008.
39.Arakawa, N.S.; Schorr, K.; Ambrosio, S.R.; Merfort, I.; Da Costa, F.B. Further sesquiterpene lactones from Viguiera robusta and the potential anti-inflammatory activity of a heliangolide: inhibition of human neutrophil elastase release. Zeitschrift für Naturforschung, v. 63c, pp. 533-538, 2008.
38.Chaves, J.S.; Da Costa, F.B. A proposal for the quality control of Tanacetum parthenium (feverfew) and its hydroalcoholic extract. Revista Brasileira de Farmacognosia, v. 18, pp. 360-366, 2008. 
37.Tirapelli, C.R.; Filho, M.A.N.; Bonaventura, D.; Melo, M.C.C.; Ambrosio, S.R.; Oliveira, A.M.; Bendhack, L.M.; Da Costa, F.B. Pimaradienoic acid inhibits vascular contraction and induces hypotension in normotensive rats. Journal of Pharmacy and Pharmacology, v. 60, pp. 453-459, 2008. 
36.Ambrosio, S.R.; Oki, Y.; Heleno, V.C.G.; Chaves, J.S.; Nascimento, P.G.B.D.; Lichston, J.E.; Constantino, M.G.; Varanda, E.M.; Da Costa, F.B. Constituents of glandular trichomes of Tithonia diversifolia: relationships to herbivory and antifeedant activity. Phytochemistry, v. 69, pp. 2052-2060, 2008. 
35. Ambrosio, S.R. ; Arakawa, Nilton S.; Esperandim, V.R.; Albuquerque, S.; Da Costa, F.B. Trypanocidal activity of pimarane diterpenes from Viguiera arenaria (Asteraceae). Phytotherapy Research, v. 22, pp. 1413-1415, 2008. 
34. Hristozov, D.; Da Costa, F.B.; Gasteiger, J. Sesquiterpene lactones-based classification of the family Asteraceae using neural networks and k-nearest neighbors. Journal of Chemical Information and Modeling, v. 47, pp. 9-19, 2007.
33. Tirapelli, C.R.; Andrade, C.R.; Cassano, A.O.; Souza, F.A.; Ambrosio, S.R.; Da Costa, F.B.; Oliveira, A.M. Antispasmodic and relaxant effects of the hydroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. Journal of Ethnopharmacology, v. 110, pp. 23-29, 2007.
32.Stefani, R.; Nascimento, P.G.B.D.; Da Costa, F.B. Elucidação estrutural de substâncias orgânicas com auxílio de computador: evoluções recentes. Química Nova, v. 30, pp. 1347-1356, 2007.
31. Valerio, D.; Cunha, T.M.; Arakawa, N.S.; Lemos, H.P.; Da Costa, F.B.Parada, C.A.; Ferreira, S.H.; Cunha, F.Q.; Verri, W.A. Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism. European Journal of Pharmacology, v. 562, pp. 155-163, 2007.
30.Castelucci, S.; Rogerio, A.P.; Ambrosio, S.R.; Arakawa, N.S.; Lira, S.P.; Faccioli, L.H.; Da Costa, F.B. Anti-inflammatory activity of Dasyphyllum brasiliensis (Asteraceae) on acute peritonitis induced by beta-glucan from Histoplasma capsulatumJournal of Ethnopharmacology, v. 112, pp. 192-198, 2007. 
29.Schorr, K.; Merfort, I.; Da Costa, F.B. A novel dimeric melampolide and further terpenoids from Smallanthus sonchifolius (Asteraceae) and the inhibition of the transcription factor NF-kB. Natural Product Communications, v. 2, pp. 367-374, 2007. 
28.Taleb, S.H.; Schorr, K.; Da Costa, F.B.; Oliveira, D.C.R. Detection of flavonoids in glandular trichomes of Chromolaena species (Eupatorieae, Asteraceae) by reversed-phase high-performance liquid chromatography. Revista Brasileira de Ciências Farmacêuticas, v. 43, pp. 315-321, 2007.
27.Stefani, R.; Da Costa, F.B. Melampolides from Ichthyothere terminalis (Asteraceae, Heliantheae). Biochemical Systematics and Ecology, v. 34, pp. 757-759, 2006.
26.Ambrosio, S.R.; Tirapelli, C.R.; Da Costa, F.B.; Oliveira, A.M. Kaurane and pimarane-type diterpenes from the Viguiera species inhibit vascular smooth muscle contractility. Life Sciences, v. 79, pp. 925-933, 2006.
25.Rogerio, A.P.; Fontanari, C.; Melo, M.C.C.; Ambrosio, S.R.; Souza, G.E.P.; Pereira, P.S.; França, S.C.; Da Costa, F.B.; Faccioli, L.H. Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. Journal of Pharmacy and Pharmacology, v. 58, pp. 1265-1273, 2006.
24. Stefani, R.; Schorr, K.; Tureta, J.M.; Vichnewski, W.; Merfort, I.; Da Costa, F.B. Sesquiterpene lactones from Dimerostemma species (Asteraceae) and in vitro potential anti-inflammatory activities. Zeitschrift für Naturforschung, v. 61, pp. 647-652, 2006.
23.Schorr, K.; Da Costa, F.B. Quantitative determination of enhydrin in leaf rinse extracts and glandular trichomes of Smallanthus sonchifolius (Asteraceae) by reversed-phase high performance liquid chromatography. Phytochemical Analysis, v. 16, pp. 161-165, 2005.
22.Da Costa, F.B.; Terfloth, L.; Gasteiger, J. Sesquiterpene lactone-based classification of three Asteraceae tribes: a study based on self-organizing neural networks applied to chemosystematics. Phytochemistry, v. 66, pp. 345-353, 2005.
21.Tirapelli, C.R.; Ambrosio, S.R.; Coutinho, S.T.; Oliveira, D.C.R.; Da Costa, F.B.; Oliveira, A.M. Pharmacological comparison of the vasorelaxant action displayed by kaurenoic acid and pimaradienoic acid. Journal of Pharmacy and Pharmacology, v. 57, pp. 997-1004, 2005. 
20. Schorr, K.; Rott, A.; Da Costa, F.B.; Merfort, I. Optimisation of a human neutrophil elastase assay and investigation of the effect of sesquiterpene lactones. Biologicals, v. 33, pp. 175-184, 2005.
19.Ambrosio, S.R.; Schorr, K.; Da Costa, F.B. Terpenoids of Viguiera arenaria (Asteraceae). Biochemical Systematics and Ecology, v. 32, pp. 221-224, 2004.
18.Tirapelli, C.R.; Ambrosio, S.R.; Da Costa, F.B.; Oliveira, A.M. Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on the aorta. Pharmacology, v. 70, pp. 31-38, 2004.
17.Tirapelli, C.R.; Ambrosio, S.R.; Da Costa, F.B.; Coutinho, S.T.; Oliveira, D.C.R.; Oliveira, A.M. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta. European Journal of Pharmacology, v. 492, pp. 233-241, 2004.
16.Da Costa, F.B.; Binev, Y.; Gasteiger, J.; Aires-de-Sousa, J. Structure-based predictions of 1H NMR chemical shifts of sesquiterpene lactones using neural networks. Tetrahedron Letters, v. 45, pp. 6931-6935, 2004.
15.Ambrosio, S.R.; Tirapelli, C.R.; Coutinho, S.T.; Oliveira, D.C.R.; Oliveira, A.M.; Da Costa, F.B. Role of the carboxylic group in the antispasmodic and vasorelaxant action displayed by kaurenoic acid. Journal of Pharmacy and Pharmacology, v. 56, pp. 1407-1413, 2004.
14.Siedle, B.; García-Piñeres, A.J.; Murillo, R.; Schulte-Monting, J.; Castro, V.; Rüngeler, P.; Klaas, C.A.; Da Costa, F.B.; Kisiel, W.; Merfort, I. Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kB. Journal of Medicinal Chemistry, v. 47, pp. 6042-6054, 2004.
13.Stefani, R.; Eberlin, M.N.; Tomazela, D.M; Da Costa, F.B. Eudesmanolides from Dimerostemma vestitumJournal of Natural Products, v. 66, pp. 401-403, 2003.
12.Spring, O.; Zipper, R.; Conrad, J.; Vogler, B.; Da Costa, F.B. Sesquiterpene lactones from glandular trichomes of Viguiera radula (Heliantheae; Asteraceae). Phytochemistry, v. 62, pp. 1185-1189, 2003.
11.Schorr, K.; Da Costa, F.B. A proposal for chemical characterization and quality evaluation of botanical raw materials using glandular trichome microsampling of yacón (Polymnia sonchifolia, Asteraceae), an Andean medicinal plant. Revista Brasileira de Farmacognosia, v. 13, pp. 1-3, 2003.
10.Tirapelli, C.R.; Ambrosio, S.R.; Da Costa, F.B.; Oliveira, A.M. Inhibitory action of kaurenoic acid from Viguiera robusta (Asteraceae) on phenylephrine-induced rat carotid contraction. Fitoterapia, v. 73, pp. 56-62, 2002.
09.Schorr, K.; García-Piñeres, A. J.; Siedle, B.; Merfort, I.; Da Costa, F.B. Guaianolides from Viguiera gardneri inhibit the transcription factor NF-kB. Phytochemistry, v. 60, pp. 733-740, 2002.
08.Ambrosio, S.R.; Tirapelli, C.R.; Bonaventura, D.; Oliveira, A.M.; Da Costa, F.B. Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibt rat carotid contraction. Fitoterapia, v. 73, pp. 484-489, 2002.
07.Spring, O.; Zipper, R.; Reeb, S.; Vogler, B.; Da Costa, F.B. Sesquiterpene lactones and a myoinositol from the glandular trichomes of four Viguiera quinqueremis (Heliantheae; Asteraceae). Phytochemistry, v. 57, pp. 267-272, 2001.
06.Da Costa, F.B.; Schorr, K.; Arakawa, N.S.; Schilling, E.E.; Spring, O. Infraspecific variation in the chemistry of glandular trichomes of two Brazilian Viguiera species (Heliantheae; Asteraceae). Journal of the Brazilian Chemical Society, v. 12, pp. 403-407, 2001.
05.Schilling, E.E.; Da Costa, F.B.; Lopes, N.P.; Heise, P.J. Brazilian species of Viguiera (Asteraceae) exhibit low levels of ITS sequence variation. Edinburgh Journal of Botany, v. 57, pp. 323-332, 2000.
04.Da Costa, F.B.; Ito, I.Y.; André, R.F.G.; Vichnewski, W.; Herz, W. Constituents of Viguiera species with antibacterial activity. Fitoterapia, v. 69, pp. 86-87, 1998.
03. Da Costa, F.B.; Albuquerque, S.; Vichnewski, W. Diterpenes and synthetic derivatives from Viguiera aspillioides with trypanomicidal activity. Planta Medica, v. 62, pp. 557-559, 1996.
02.Da Costa, F.B.; Vichnewski, W.; Herz, W. Constituents of Viguiera aspillioides and V. robustaBiochemical Systematics and Ecology, v. 24, pp. 585-587, 1996.
01.Da Costa, F.B.; Dias, D.A.; Lopes, J.L.C.; Vichnewski, W. Flavonoids and heliangolides from Lychnophora diamantinanaPhytochemistry, v. 34, pp. 261-263, 1993.

Oliveira, R.B.; Godoy, S.A.P.; Da Costa, F.B. Plantas tóxicas: conhecimento e prevenção de acidentes. 1a ed. Ribeirão Preto: Holos, 2003, 64p.

Book chapters
Casoti, R.; Guiraldeli, A.; Freitas, J.A.; Santos, F.A.; Da Costa, F.B. Topics on metabolomics. In: Diniz, M.F.F.M.; Scotti, L.; Scotti, M.T.; Alves, M.F.. (Org.). Natural products and drug discovery: from pharmacochemistry to pharmacological approaches. 1a ed., João Pessoa: Editora UFPB, 2018, p. 83-125.

Del Rio, A.; Da Costa, F.B. Molecular approaches to explore natural and food-compound modulators in cancer epigenetics and metabolism. In: K. Martinez-Mayorga; J.L. Medina-Franco (Eds.). Foodinformatics. 1st ed. Cham: Springer International Publishing, 2014, pp. 131-149. DOI: 10.1007/978-3-319-10226-9_5

Scotti, M.T.; Da Costa, F.B. Métodos in silico para elucidação estrutural de substâncias: fundamentos, metodologias e aplicações em produtos naturais e metabolômica. In: G.H.B. Souza, J.C.P. Mello, N.P. Lopes (Org.). Revisões em processos e técnicas avançadas de isolamento e determinação estrutural de ativos de plantas medicinais. Revisões em processos e técnicas avançadas de isolamento e determinação estrutural de ativos de plantas medicinais. 1a ed. Ouro Preto: EDUFOP, 2011, pp. 73-118.

Stefani, R.; Da Costa, F.B. Computer-assisted structure elucidation of organic compounds. In: C.A. Taft; C.H.T.P. Silva. (Org.). Current Methods in MedicinalChemistry and Biological Physics. 1st ed. Kerala: Research Signpost, 2007, pp. 101-124.

Da Costa, F.B. In Honor of the 90th Birthday of Professor Werner Herz. Natural Product Communications, v. 5 (5), 2010.