Publications

Original papers - highlights (click here to access the full list)

Padilla-Gonzalez, G.F.; Diazgranados, M.; Da Costa, F.B. Biogeography shaped the metabolome of the genus Espeletia: a phytochemical perspective on an Andean adaptive radiationScientific Reports, v. 7, p. 8835, 2017. DOI:10.1038/s41598-017-09431-7

Sampaio, B.L.; Edrada-Ebel, R.; Da Costa, F.B. Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants. Scientific Reports, v. 6, p. 29265, 2016. DOI: 10.1038/srep29265

Padilla-Gonzalez, G.F.; Santos, F.A.; Da Costa, F.B. Sesquiterpene lactones: more than protective plant compounds with high toxicity. Critical Reviews in Plant Sciences, v. 35, p. 01-20, 2016. DOI: 10.1080/07352689.2016.1145956

Chagas-Paula, D.A.; Oliveira, T.B.; Faleiro, D.P.V.; Oliveira, R.B.; Da Costa, F.B. Outstanding anti-inflammatory potential of selected Asteraceae species through the potent dual inhibition of cyclooxygenase-1 and 5-lipoxygenase. Planta Medica, v. 81, p. 1296-1307, 2015. DOI: 10.1055/s-0035-1546206 download the PDF file of this paper in the link at the bottom of this page.

Chagas-Paula, D.A.; Oliveira, T.B.; Zhang, T.; Edrada-Ebel, R.; Da Costa, F.B. Prediction of anti-inflammatory plants and discovery of their biomarkers by machine learning algorithms and metabolomic studies. Planta Medica, v. 81, p. 450-458, 2015. DOI: 10.1055/s-0034-1396206 - download the PDF file of this paper in the link at the bottom of this page.

Oliveira, T.B.; Gobbo-Neto, L.; Schmidt, T.J.; Da Costa, F.B. Study of chromatographic retention of natural terpenoids by chemoinformatic tools. Journal of Chemical Information and Modeling, v. 55, p. 26-38, 2015. DOI: 10.1021/ci500581q

Toledo, J.S.; Ambrosio, S.R.; Borges, C.H.G.; Manfrim, V.; Cerri, D.G.; Cruz, A.K.; Da Costa, F.B. In vitro leishmanicidal activities of sesquiterpene lactones from Tithonia diversifolia against Leishmania braziliensis promastigotes and amastigotes. Molecules, v. 19, p. 6070-6079, 2014. DOI: 10.3390/molecules19056070

Arakawa, N.S.; Gobbo-Neto, L.; Ambrosio, S.R.; Antonucci, G.A.; Sampaio, S.V.; Pupo, M.T.; Said, S.; Schmidt, T.J.; Da Costa, F.B. Unusual biotransformation products of the sesquiterpene lactone budlein A by Aspergillus species. Phytochemistry, v. 96, p. 92-100, 2013. DOI: 10.1016/j.phytochem.2013.09.022

Passoni, F.D.; Oliveira, R.B.; Chagas-Paula, D.A.; Gobbo-Neto, L.; Da Costa, F.B. Repeated-dose toxicological studies of Tithonia diversifolia (Hemsl.) A. Gray and identification of the toxic compounds. Journal of Ethnopharmacologyv. 147, p. 389-394, 2013. DOI: 10.1016/j.jep.2013.03.024

Schomburg, C.; Schuehly, W.; Da Costa, F.B.; Klempnauer, K.-H.; Schmidt, T.J. Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships. European Journal of Medicinal Chemistry, v. 63, pp. 313-320, 2013. DOI: 10.1016/j.ejmech.2013.02.018

Appezzato-da-Glóriaa, B.; Da Costa, F.B.; Silva, V.C.; Gobbo-Neto, L.; Rehder, V.L.G.; Hayashi, A.H. Glandular trichomes on aerial and underground organs in Chrysolaena species (Vernonieae – Asteraceae): structure, ultrastructure and chemical composition. Flora, v. 207, pp. 878–887, 2012. DOI: 10.1016/j.flora.2012.10.003 

Rocha, B.A.; Pupo, M.T.; Antonucci, G.A.; Sampaio, S.V.; Paiva, R.M.A.; Said, S.; Gobbo-Neto, L.; Da Costa, F.B. Microbial transformation of the sesquiterpene lactone tagitinin C by the fungus Aspergillus terreus. Journal of Industrial Microbiology & Biotechnology, v. 39, pp. 1719-1724, 2012. DOI: 10.1007/s10295-012-1165-2

Chagas-Paula, D.A.; Oliveira, R.B.; Rocha, B.A.; Da Costa, F.B. Ethnobotany, chemistry and biological activities of the genus Tithonia (Asteraceae). Chemistry & Biodiversity, v. 9, pp. 210-235, 2012. DOI: 10.1002/cbdv.201100019

Oliveira, R.B.; Chagas-Paula, D.A.; Rocha, B.A.; Franco, J.J.; Gobbo-Neto, L.; Uyemura, S.A.; Santos, W.F.; Da Costa, F.B. Renal toxicity caused by oral use of medicinal plants: the yacon example. Journal of Ethnopharmacology, v. 132, pp. 434-441, 2011. DOI: 10.1016/j.jep.2010.10.019

Chagas-Paula, D.A.; Oliveira, R.B.; Silva, V.C.; Gobbo-Neto, L.; Gasparoto, T.H.; Campanelli, A.P.; Faccioli, L.H.; Da Costa, F.B. Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones. Journal of Ethnopharmacology, v. 136, pp. 355-362, 2011. DOI: 10.1016/j.jep.2011.04.067

Ambrosio, S.R.; Stefani, R.; Heleno, V.C.G.; Menezes, M.A.; Ferreira, A.G.; Nascimento, P.G.B.D.; Magenta, M.A.G.; Da Costa, F.B. Eudesmanolides and methyl ester derivatives from Dimerostemma arnottii. Natural Product Communications, v. 5, pp. 669-675, 2010. 

Nicolete, R.; Arakawa, N.S.; Rius, C.; Nomizo, A.; Jose, P.J.; Da Costa, F.B.; Sanz, María-Jesús; Faccioli, L.H. Budlein A from Viguiera robusta inhibits leukocyte-endothelial cell interactions, adhesion molecule expression and inflammatory mediators release. Phytomedicine, v. 16, pp. 904-915, 2009. DOI: 10.1016/j.phymed.2009.04.002

Chaves, J.S.; Da Costa, F.B. A proposal for the quality control of Tanacetum parthenium (feverfew) and its hydroalcoholic extract. Revista Brasileira de Farmacognosia, v. 18, pp. 360-366, 2008. DOI: 10.1590/S0102-695X2008000300009

Ambrosio, S.R.; Oki, Y.; Heleno, V.C.G.; Chaves, J.S.; Nascimento, P.G.B.D.; Lichston, J.E.; Constantino, M.G.; Varanda, E.M.; Da Costa, F.B. Constituents of glandular trichomes of Tithonia diversifolia: relationships to herbivory and antifeedant activity. Phytochemistry, v. 69, pp. 2052-2060, 2008. DOI: 10.1016/j.phytochem.2008.03.019

Stefani, R.; Nascimento, P.G.B.D.; Da Costa, F.B. Elucidação estrutural de substâncias orgânicas com auxílio de computador: evoluções recentes. Química Nova, v. 30, pp. 1347-1356, 2007. DOI: 10.1590/S0100-40422007000500048

Castelucci, S.; Rogerio, A.P.; Ambrosio, S.R.; Arakawa, N.S.; Lira, S.P.; Faccioli, L.H.; Da Costa, F.B. Anti-inflammatory activity of Dasyphyllum brasiliensis (Asteraceae) on acute peritonitis induced by beta-glucan from Histoplasma capsulatum. Journal of Ethnopharmacology, v. 112, pp. 192-198, 2007. DOI: 10.1016/j.jep.2007.01.037

Stefani, R.; Da Costa, F.B. Melampolides from Ichthyothere terminalis (Asteraceae, Heliantheae). Biochemical Systematics and Ecology, v. 34, pp. 757-759, 2006. DOI: 10.1016/j.bse.2006.05.009

Stefani, R.; Schorr, K.; Tureta, J.M.; Vichnewski, W.; Merfort, I.; Da Costa, F.B. Sesquiterpene lactones from Dimerostemma species (Asteraceae) and in vitro potential anti-inflammatory activities. Zeitschrift für Naturforschung C, v. 61, pp. 647-652, 2006.

Schorr, K.; Da Costa, F. B. Quantitative determination of enhydrin in leaf rinse extracts and glandular trichomes of Smallanthus sonchifolius (Asteraceae) by reversed-phase high performance liquid chromatography. Phytochemical Analysis, v. 16, pp. 161-165, 2005. DOI: 10.1002/pca.836 
 
Da Costa, F.B.; Terfloth, L.; Gasteiger, J. Sesquiterpene lactone-based classification of three Asteraceae tribes: a study based on self-organizing neural networks applied to chemosystematics. Phytochemistry, v. 66, pp. 345-353, 2005. DOI: 10.1016/j.phytochem.2004.12.006

Ambrosio, S.R.; Schorr, K.; Da Costa, F.B. Terpenoids of Viguiera arenaria (Asteraceae). Biochemical Systematics and Ecology, v. 32, pp. 221-224, 2004. DOI: 10.1016/S0305-1978(03)00139-X

Da Costa, F.B.; Binev, Y.; Gasteiger, J.; Aires-de-Sousa, J. Structure-based predictions of 1H NMR chemical shifts of sesquiterpene lactones using neural networks. Tetrahedron Letters, v. 45, pp. 6931-6935, 2004. DOI: 10.1016/j.tetlet.2004.07.082

Ambrosio, S.R.; Tirapelli, C.R.; Coutinho, S.T.; Oliveira, D.C.R.; Oliveira, A.M.; Da Costa, F.B. Role of the carboxylic group in the antispasmodic and vasorelaxant action displayed by kaurenoic acid. Journal of Pharmacy and Pharmacology, v. 56, pp. 1407-1413, 2004. DOI: 10.1211/0022357044715

Stefani, R.; Eberlin, M.N.; Tomazela, D.M; Da Costa, F.B. Eudesmanolides from Dimerostemma vestitum. Journal of Natural Products, v. 66, pp. 401-403, 2003. DOI: 10.1021/np020304u

Schorr, K.; García-Piñeres, A. J.; Siedle, B.; Merfort, I.; Da Costa, F.B. Guaianolides from Viguiera gardneri inhibit the transcription factor NF-kB. Phytochemistry, v. 60, pp. 733-740, 2002. DOI: 10.1016/S0031-9422(02)00197-8

Da Costa, F.B.; Schorr, K.; Arakawa, N.S.; Schilling, E.E.; Spring, O. Infraspecific variation in the chemistry of glandular trichomes of two Brazilian Viguiera species (Heliantheae; Asteraceae). Journal of the Brazilian Chemical Society, v. 12, pp. 403-407, 2001. DOI: 10.1590/S0103-50532001000300012

Book
Oliveira, R.B.; Godoy, S.A.P.; Da Costa, F.B. Plantas tóxicas: conhecimento e prevenção de acidentes. 1a ed. Ribeirão Preto: Holos, 2003, 64p.

Book chapters
Del Rio, A.; Da Costa, F.B. Molecular approaches to explore natural and food-compound modulators in cancer epigenetics and metabolism. In: Martinez-Mayorga, K.; Medina-Franco, J.L. (Eds.). Foodinformatics1st ed. Cham: Springer International Publishing, 2014, p. 131-149.

Scotti, M.T.; Da Costa, F.B. Métodos in silico para elucidação estrutural de substâncias: fundamentos, metodologias e aplicações em produtos naturais e metabolômica. In: Souza, G.H.B.; Mello, J.C.P.; Lopes, N.P. (Org.). Revisões em processos e técnicas avançadas de isolamento e determinação estrutural de ativos de plantas medicinais. Revisões em processos e técnicas avançadas de isolamento e determinação estrutural de ativos de plantas medicinais. 1a ed. Ouro Preto: EDUFOP, 2011, p. 73-118.

Stefani, R.; Da Costa, F.B. Computer-assisted structure elucidation of organic compounds. In: Taft, C.A.; Silva, C.H.T.P. (Org.). Current Methods in Medicinal Chemistry and Biological Physics. 1st ed. Kerala: Research Signpost, 2007, p. 101-124.

Poster presentations - highlights
Casoti, R.; Heiden, G.; Da Costa, F. B. Chemotaxonomic study of Baccharis subgen. Tarchonanthoides (Asteraceae) based on metabolomics approach and multivariate analysis. In: 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2014, Guimarães, Portugal. Book of Abstracts, v. P1M20. p. 124.

Santos, F.A.; Faleiro, D.P.V.; Da Costa, F.B. Metabolomics and chemometrics applied to the chemotaxonomy of the genus Aldama (Asteraceae) and classification according to geographical origin. In: 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2014, Guimarães, Portugal. Book of Abstracts, v. P1M7. p. 112-113.

Oliveira, T.B.; Chagas-Paula, D.A.; Rosa, A.L.; Gobbo-Neto, L.; Schmidt, T.J.; Da Costa, F.B. Temporal characteristics of a natural products in-house database. In: 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2013, Münster, Germany. Planta Medica, v. 79. SL26.

Oliveira, R.B.; Chagas-Paula, D.A.; Oliveira, T.B.; Da Costa, F.B. Effects of sesquiterpene lactones on lipoxygenase activity. In: 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2013, Münster, Germany. Planta Medica, v. 79. PN73.

Da Costa, F.B.; Oliveira, T.B. BAnco de DAdos de PROdutos Naturais (BADAPRON) e inteligência artificial na desreplicação de matrizes vegetais. In: 35a Reunião Anual da Sociedade Brasileira de Química, 2012, Águas de Lindóia, SP, Brazil. Resumos, QPN-014.

Chagas-Paula, D.A.; Zhang, T.; Faleiro, D.P.V.; Oliveira, T.B.; Da Costa, F.B.; Edrada-Ebel, R. Metabolomic approach demystifies chemical features of anti-inflammatory Asteraceae plants with interesting mechanism of action. In: 2012 Phytochemical Society of Europe Congress on Bio-communication, 2012, Cádiz, Spain. Waters. Genomics, proteomics and metabolomics. Biotechnological implications, p. 54.

Oliveira, T.B.; Siems, K.; Da Costa, F.B. HPLC Retention time prediction of natural compounds: a tool for dereplication of complex organic matrices. In: 3rd Brazilian Conference on Natural Products, 2011, Ouro Preto, MG, Brazil. Abstracts, p. 252.

Chagas-Paula, D.A.; Oliveira, R.B.; Gobbo-Neto, L.; Silva, V.C.; Passoni, F.D.; Da Costa, F.B. The disconnection approach: integrationism and reductionism in the study of medicinal plants. In: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2010, Berlin, Germany. Planta Medica, v. 76, p. P-343.

Oliveira, R.B.; Chagas-Paula, D.A.; Gasparato, T.; Faccioli, L.H.; Da Costa, F.B. Effect of Smallanthus sonchifolius extracts on croton oil-induced oedema and neutrophil migration to the ear skin tissue of mice. In: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2010, Berlin, Germany. Planta Medica, v. 76, p. P-363.

Gobbo-Neto, L.; Silva, V.C.; Chagas-Paula, D.A.; Oliveira, R.B.; Da Costa, F.B. Dereplication of secondary metabolites of foliar extracts from Tithonia diversifolia and Smallanthus sonchifolius (Asteraceae) by HPLC-DAD-MS. In: 2nd Brazilian Conference on Natural Products, 2009, São Pedro, SP, Brazil. Abstracts, p. PS-030.

Arakawa, N.S.; Gobbo-Neto, L.; Carollo, C.A.; Antonucci, G.A.; Sampaio, S.V.; Pupo, M.T.; Said, S.; Da Costa, F.B. Increasing chemical diversity through biotransformation of terpenoids by fungi. In: 7th Joint Meeting of GA, AFERP, ASP, PSE & SIF, 2008, Athens, Greece. Planta Medica, v. 74. p. 1163.

Oliveira, R.B.; Chagas-Paula, D.A.; Rocha, B.A.; Secatto, A.; Da Costa, F.B. In vitro comparison of the anti-inflammatory activity of the glandular content and polar free-gland extracts of Tithonia diversifolia and Smallanthus sonchifolius. In: XX Simpósio de Plantas Medicinais do Brasil X International Congress of Ethnopharmacology, 2008, São Paulo, SP, Brazil. Annals and Program.

Ambrosio, S.R.; Chaves, J.S.; Lichston, J.E.; Oki, Y.; Varanda, E.M.; Da Costa, F.B. Chemical profile and seasonal variation in glandular trichomes content, herbivory on the leaves and novel constituents of Tithonia diversifolia. In: 50 Years of the Phytochemical Society of Europe, 2007, Cambridge, England. Abstracts, p. P50.

Arakawa, N.S.; Ambrosio, S.R.; Gobbo-Neto, L.; Carollo, C.; Said, S.; Da Costa, F.B. Biotransformed products from terpenoids by fungi. In: 1st Brazilian Conference on Natural Products & XXVII RESEM, 2007, São Pedro, SP, Brazil. Abstracts, p. BOSD-4.

Da Costa, F.B.; Hristozov, D.; Stefani, R.; Gasteiger, J. Prediction of retention times of natural compounds in reversed-phase liquid chromatography. In: 2nd German Conference on Chemoinformatics, 2006, Goslar, Germany. Book of Abstracts, p. 49-49.

Da Costa, F.B.; Binev, Y.; Gasteiger, J.; Aires-de-Sousa, J. Neural networks for the prediction of 1H NMR chemical shifts of sesquiterpene lactones. In: 7th International Conference on Chemical Structures, 2005, Noordwijkerhout, Netherlands. Abstracts, p. P28.

Da Costa, F.B.; Binev, Y.; Gasteiegr, J.; Aires-de-Sousa, J. Estimation of 1H NMR chemical shifts of sesquiterpene lactones using neural networks. In: 18. Gesellschaft Deutscher Chemiker (GDCh)-Chemie-Information-Computer-(CIC)-Workshop, 2004, Boppard am Rhein, Germany. Abstracts, p. 11.

Tirapelli, C.R.; Ambrosio, S.R.; Da Costa, F.B.; Oliveira, A.M. Antispasmodic and relaxant effect of kaurenoic acid isolated from Viguiera robusta on rat carotid. In: 4th Congress of Pharmaceutical Sciences, 2003, Ribeirão Preto, SP, Brazil. Brazilian Journal of Pharmaceutical Sciences, suppl. 2, v. 39. p. 148.

Spring, O.; Schorr, K.; Da Costa, F.B. Infraspecific variation in the chemistry of glandular trichomes of two Brazilian Viguiera species (Asteraceae). In: 22nd IUPAC International Symposium on the Chemistry of Natural Products, 2000, São Carlos, SP, Brazil. Abstract Publication, p. OPA01.
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Fernando B. da Costa,
Oct 20, 2015, 1:27 PM
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Fernando B. da Costa,
May 7, 2015, 5:57 AM